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A significant problem sheet with developing this as a combination product arises from the fact that titanium dioxide and porfimer sodium need to be administered by different routes. The generic ingredient in Photofrin is purified porfimer sodium.
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Toxicological analysis thus revealed lethal dose levels of motexafin gadolinium, toxic exposure levels of porfimer sodium, and multiple other coingested substances at nontoxic dose levels. Apparently, dangerous substance use can cause lack color or loss of strength as a side to effect.